Midlife, Reconsidered
Midlife is often framed as a period of loss, but emerging research suggests a more nuanced story. Understanding the biological changes of menopause opens the door to better health and...
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From Biology to Formulation - Designing support around the body’s own mechanisms
The most effective solutions for vulvovaginal health begin with biology. By understanding how tissue responds to hormones and natural signaling pathways, formulation science can support the body’s own mechanisms rather...
Genitourinary Syndrome of Menopause (GSM): A Tissue-Level View
GSM names a symptom cluster, not a mechanism. Beneath it are five tissue systems that change at different rates in different women — which is why the same diagnosis produces...
Intracrine Hormone Signaling in Vaginal Tissue - And What It May Mean for the Vulva
Vulvar and vaginal tissue carries the enzymes to make its own androgens from DHEA. The hormones act inside the cell that made them and never enter circulation — which is...
Why Isn't Estrogen Enough for Midlife Vulvar and Vaginal Health?
Estrogen therapy often improves comfort while sensation and desire stay where they were. That isn't a dosing problem, the vagina and vulva also need androgens - testosterone and DHT -...
Why do Vaginal Moisturizers and Lubricants Stop Short of Full Relief?
Many women rely on moisturizers or lubricants for relief from dryness. Understanding why these solutions do not fix the issues reveal deeper changes happening within vulvovaginal tissue.