DHEA Benefits for Women: Beyond Vaginal Use
DHEA for Women: Benefits, Uses, and What the Evidence Actually Shows Beyond vaginal use: a science-based guide to DHEA in midlife DHEA is often described as an “anti-aging hormone,” an...
Midlife Vaginal and Vulvar Health Explained
our thesis
Why DHEA for the Vulva?
Human vaginal tissue can metabolize DHEA. The vulvar vestibule is hormone-responsive and the major site of postmenopausal penetrative pain. Intravaginal DHEA has also been shown to improve vestibular tissue and pain. Vulvar delivery as a logical next application of the science - the approach behind Restore.
Articles
Perimenopause and Vulvar Health: Why Dryness, Irritation, and Pain Can Begin Before Menopause
Perimenopause can affect vulvar comfort before periods stop. Learn what the evidence shows about dryness, irritation, pain, hormone-responsive tissue, and why the vulva and vagina are not identical treatment targets.
What Changes in Perimenopause? The Part Nobody Explains
Your bloodwork says nothing is happening. Your body disagrees. Both are correct — and the order things change in explains why.
Why Can Sex in Midlife Hurt? What the Evidence Actually Shows
We were told it's thinning tissue and low estrogen. But pain with sex correlates poorly with either — and for many women it's coming from the entrance, which is part...
Or, start with what's happening for you.
What's going on with you?
Clear, referenced answers to what's actually happening in your body — written by a clinician and researcher.
I'm dry, and it came on gradually
Lubricants and moisturizers stopped working
I use vaginal estrogen and it only partly helps
I have burning and urgency, but my cultures come back negative
I don't think about sex anymore
My periods are changing and I don't know what's happening
My symptoms come and go with stress and sleep
I want to understand vulvovaginal biology properly
What is DHEA, and is it safe?
Frequently asked questions
Is vaginal dryness after menopause inevitable?
No. Tissue changes are common, but severity and progression vary widely between women — and the systems involved differ, which is why the same treatment produces such different results.
Why do my hormone levels look normal when I have symptoms?
Because vulvar and vaginal tissue makes hormones inside its own cells, where they act and are then broken down without entering the bloodstream. A blood test measures circulation, not tissue-level activity.
Is genitourinary syndrome of menopause - GSM - the same as vaginal atrophy?
"Vulvovaginal atrophy" is an older term that focused on tissue thinning. In 2014 a clinical consensus panel replaced it with genitourinary syndrome of menopause, because the older name described appearance rather than function and left out the urinary tract entirely — even though the urethra and bladder change alongside vulvar and vaginal tissue.
Where can I read the research behind these articles?
Every article carries a reference list with DOIs, and states where evidence is established and where it's inference. Our published research is on the Science page.
Who writes this
Laura Kelly, DAOM, L.Ac., Dipl. O.M.
A California-licensed primary care provider and nationally board-certified clinician with a clinical focus on women's health and healthy aging.
Research Scholar at the Ronin Institute.
Developer of the Drive–Capacity Model of Midlife Female Sexual Function, published in Research Connections, April 2026 (Oxford University Press).
Every article here carries references to published research and states plainly where evidence is established and where it is inference.